Subject Populations

The New England Family Study, formerly known as the National Collaborative Perinatal Project, began in the 1960s, with the intention that a large longitudinal study of thousands of mothers and infants could help reduce childhood and adult disease. This fetal to adulthood design allows us to study potential moderating effects of childhood social adversities in the context of shared genes and environments between discordant siblings. This New England cohort was an unselected community sample of pregnancies and thus is highly representative of the general population. Although the sample is primarily Caucasian (86%) given the catchmant areas at the time, there was no selection by ethnicity (13% are African American).

Community-based studies (MDD+OB, PBS, tVNS):
Twenty female volunteers ages 25 to 40 will be recruited from the general population. Volunteers will currently be in a recurrent major depressive episode (per diagnosis by an experienced lab-based clinician) and unmedicated.

Partners BioBank Healthy Aging Translational Cohort:
Subjects recruited from Partners primary and specialty care clinics. These subjects have banked DNA and other biosamples and their content includes state-of-the-art language regarding genetics, integration of electronic medical records with research data, and the ability to recontact subjects. We envision ultimately a cohort of 10,000 subjects that will be known as the Healthy Aging Translational Cohort (HATCH). We are initially examining a cohort of 5,000 subjects.