Jill M. Goldstein, Ph.D.

Principal Investigator and Lab Director

Jill M. Goldstein, Ph.D.

Jill M. Goldstein, Ph.D. is a Professor of Psychiatry and Medicine at Harvard Medical School and Director of Research at the Connors Center for Women’s Health and Gender Biology at Brigham and Women’s Hospital (BWH).

As a clinical neuroscientist with doctoral training in psychiatric epidemiology and clinical psychopathology at Columbia University, and post-doctoral training in neuroscience and brain imaging at Harvard Medical School, Dr. Goldstein is an internationally recognized expert in understanding sex differences in health and diseases associated with the central nervous system. Specifically, Dr. Goldstein’s investigations have focused on characterizing sex differences in the development and adult functioning of the human brain and how these differences contribute to understanding sex differences in psychiatric and neurologic disorders and their comorbidity with general medical disorders.

Her program of research, called the Clinical Neuroscience Laboratory of Sex Differences in the Brain (http://cnl-sd.bwh.harvard.edu) consists of an interdisciplinary team of investigators, integrating structural and functional brain imaging studies, psychophysiology, neuroendocrine studies of hormones and brain function, genetics, immune biomarkers, and collaborative efforts with basic neuroscientists studying genes, hormones, immune pathways and the brain (http://mddscor.bwh.harvard.edu).  Brain circuitries under current investigation include the stress response circuitry, memory and working memory (and brain aging and risk for Alzheimer's disease), and reward circuitry implicated in the neural circuitry of obesity and metabolic disturbance.  This work has been funded by the National Institutes of Health for nearly 30 years. She has published over 135 articles, chapters and other original and peer-reviewed work in these areas.

Dr. Goldstein is also an administrative and educational leader in women’s health and sex differences in medicine, locally and nationally. At BWH, she has built a unique research infrastructure to foster collaborative efforts to understand mechanisms that explain sex differences in health and disease across disciplines and methods of study. She also is the Principal Investigator of a Harvard-wide junior faculty training program on building interdisciplinary careers in women’s health called, “Hormones and Genes in Women’s Health:  From Bench to Bedside” and is committed to training the next generation in this arena in medicine.

Selected Publications

Goldstein, JM, Seidman, LJ, Horton, NJ, Makris, M, Kennedy, DN, Caviness, VS, Faraone, SV, Tsuang, MT. Normal sexual dimorphism of the adult human brain assessed by in-vivo magnetic resonance imaging. Cerebral Cortex, 2001, 11:490-497. (Also, awarded the cover page from this work.) PMID: 11375910

Goldstein, JM, Seidman, LJ, O’Brien, L, Horton, N, Kennedy, DN, Makris, N, Caviness, VS, Faraone, SV, Tsuang, MT. Impact of normal sexual dimorphisms on sex differences in structural brain abnormalities in schizophrenia assessed by magnetic resonance imaging. Archives of General Psychiatry, 2002; 59:154-164. PMID: 11825137

Goldstein, JM, Jerram, M, Poldrack, R, Kennedy, DN, Seidman, LJ, Makris, N. Hormonal cycle modulates arousal circuitry in women using fMRI.  Journal of Neuroscience, 2005;25:9309-9316. PMID: 16207891

Goldstein, JM.  Sex, hormones, and affective arousal dysfunction in schizophrenia.  Hormones and Behavior, 2006; 50; 612-622. PMID: 16876167

Goldstein, JM, Seidman, JL, Makris N, Ahern, T. O’Brien, LM, Caviness, VS, Kennedy, DN, Faraone, SV, Tsuang, MT.  Hypothalamic abnormalities in schizophrenia: Sex effects & genetic vulnerability, Biological Psychiatry, 2007: 61: 935-945; Awarded the cover page image. PMID: 17046727

Goldstein, JM, Buka, SL, Seidman, LJ, Tsuang, MT.  Specificity of familial transmission of schizophrenia psychosis spectrum and affective psychoses in the New England Family Studies high risk design. Archives of General Psychiatry 2010; 67:458-467. PMCID: PMC3049996

Goldstein, JM, Jerram, M, Abbs, B, Whitfield-Gabrieli, S, Makris, N.  Sex differences in stress response circuitry activation dependent on female hormonal cycle. Journal of Neuroscience 2010, 30 (2): 431-438. PMCID: PMC2827936

Holsen, LM, Spaeth, SB, Lee, J-H, Ogden, LA, Klibanski, A, Whitfield-Gabrieli, S, Goldstein, JM. Stress response circuitry hypoactivation related to hormonal dysfunction in women with major depression. Journal of Affective Disorders 2011 Jun;131(1-3):379-87. PMCID: PMC3073153

Goldstein, JM, Cherkerzian, S, Seidman, LJ, Petryshen, TL, Fitzmaurice, G, Tsuang, MT, Buka, SL. Sex-Specific Rates of Transmission of Psychosis in The New England High-Risk Family. Schizophr Res. 2011 May; 128 (1-3):150-5. PMCID: PMC3085650

Goldstein JM, Cherkerzian S, Buka S, Fitzmaurice G, Susser E, Hornig M, Gillman M, Factor-Litvak P, Sloan RP.  Sex-specific impact of maternal-fetal risk factors on depression and cardiovascular risk 40 years later. Journal of Developmental Origins of Health and Disease 2011; 2 (6): 353–364. PMCID: PMC3558934

Abbs B, Liang L, Makris N, Tsuang M, Seidman LJ, Goldstein JM. Covariance modeling of MRI brain volumes in memory circuitry in schizophrenia: Sex differences are critical. NeuroImage 2011; 56(4):1865-74. PMCID: PMC3113542

Holsen LM, Savage CR, Martin LE, Bruce AS, Lepping RJ, Ko E, Brooks WM, Butler MG, Zarcone JR, Goldstein JM. Importance of Reward and Prefrontal Circuitry in Hunger and Satiety: Prader-Willi Syndrome vs. Simple Obesity. International Journal of Obesity 2011, October 25. PMCID: PMC3270121

Holsen LM, Lawson EA, Ko E, Blum J, Makris N, Fazeli, PK, Klibanksi A, Goldstein JM. Food motivation circuitry hypoactivation related to hedonic and non-hedonic aspects of hunger and satiety in women with active and weight-restored anorexia nervosa. J Psychiatry and Neuroscience. 2012 Sept;37(5): 322-32. PMCID: PMC3447131

Holsen LM, Lee J-H, Spaeth SB, Ogden LA, Klibanski A, Whitfield-Gabrieli S, Sloan RP, Goldstein JM. Brain hypoactivation, autonomic nervous system dysregulation, and gonadal hormones in depression: a preliminary study. Neurosci Lett. 2012 Apr 11;514(1):57-61. PMCID: PMC3319257

Makris N, Swaab DF, van der Kouwe A, Abbs B, Boriel D, Handa R, Tobet S, Goldstein JM. Volumetric Parcellation Methodology of the Human Hypothalamus in Neuroimaging: Normative Data and Sex Differences. NeuroImage 2013 (69): 1-10. PMCID: PMC3575213

Holsen LM, Lancaster K, Klibanski A, Whitfield-Gabrieli S, Cherkerzian, S, Buka S, Goldstein JM. HPA-Axis Hormone Modulation of Stress Response Circuitry Activity in Women with Remitted Major Depression. Neuroscience. 2013 Oct 10; 250:733-42. PMCID: PMC3772711

Goldstein, JM, Handa, RJ, Tobet, SA. Disruption of Fetal Hormonal Programming (Prenatal Stress) Implicates Shared Risk for Sex Differences in Depression and Cardiovascular Disease. Front Neuroendocrin. 2014; 35(1); 140-158. PMCID: PMC3917309

Goldstein, JM, Cherkerzian, S, Seidman, LJ, Donatelli, JA, Remington, A, Tsuang, MT, Hornig, M, Buka, S. Prenatal Maternal Immune Disruption and Sex-Dependent Risk for Psychoses. Psychological Medicine, 2014. In press.